Evaluation of Acute Toxicity of Hydro-Ethanolic Extract of Tricholepis glaberrima

Abstract

Tricholepis glaberrima is used to treat skin conditions and male infertility. The aim of the research was to evaluate whether the hydro ethanolic extract of aerial parts of Tricholepis glaberrima could cause acute oral toxicity in swiss albino mice and how it affected their behavior. The acute toxicity trials were conducted according to OECD guidelines 423, with a single oral dosage and a 14-day follow-up. After 24 hours, body weight, food and water consumption, signs of toxicity, and mortality were reported. Up to a dosage of 2000 mg/kg, oral administration resulted in no treatment-related mortality in animals. In the acute toxicity study, the hydro-ethanolic extract of aerial parts of Tricholepis glaberrima had an LD50 of greater than 2000 mg/kg, indicating that extract from this plant is acceptable for use in conventional medicine.