From Biomarkers to Pharmacological Targets: Long Non-Coding RNAs in Disease Intervention and Drug Development

Abstract

The realm of molecular biology has witnessed a paradigm shift with the discovery and elucidation of the intricate world of long non-] coding RNAs (lncRNAs). LncRNAs have emerged as key players in the orchestration of cellular processes and, more importantly, as potential biomarkers and pharmacological targets for a myriad of diseases. In various diseases, such as cancer, neurodegenerative disorders, and cardiovascular conditions, specific lncRNAs emerge as critical regulators impacting cell proliferation, apoptosis, and immune response. The review extends to the evolving field of lncRNA therapeutics, exploring strategies for effective delivery, overcoming absorption challenges, and addressing issues related to metabolism. This comprehensive review delves into the evolving landscape of lncRNAs, exploring their diverse roles in health and disease, and highlighting their promise as diagnostic biomarkers and therapeutic targets in drug development.