Evaluation of Antiepileptic Activity of Prunus amygdalus Dry Fruit Suspension in Albino Mice

Abstract

Epilepsy, a prevalent neurological disorder, poses a substantial global health burden affecting individuals of all ages. Despite the availability of antiepileptic drugs (AEDs), a considerable proportion of patients face challenges in achieving adequate seizure control, prompting exploration into alternative therapies. This research focuses on evaluating the antiepileptic activity of Prunus amygdalus (PA) dry fruit suspension in albino mice following the induction of convulsions through maximum electric shock (MES) & isoniazidinduced tonic-clonic seizures, and strychnine-induced convulsive seizures. The study reveals that 100, 200, and 400 mg/kg doses of Prunus amygdalus suspension administered orally significantly reduces the frequency and amplitude of induced movements. The duration of convulsions was reduced significantly also for both clonic and tonic seizures as well. The antiepileptic activity of Prunus amygdalus is attributed to its impact on Na+ voltage-dependent channels or acting as an NMDA antagonist. The presence of alkaloids and flavonoids in PA suspension aligns with established evidence supporting their antiepileptic effects. This study offers insightful information into the development of plant-based alternatives for epilepsy management, paving the way for further investigations into the therapeutic potential of Prunus amygdalus in neurological disorders.