Antioxidant and Antihyperlipidemic Activities of Methanolic Extract of Rubia cordifolia Roots

Mohammed Hamed Ali; Uzma Taseen

doi:10.52816/JDVAT.2022.2202

Authors

Mohammed Hamed Ali Research Scholar, Department of Pharmacology, Shadan College of Pharmacy, JNT Hyderabad University, Hyderabad, Telangana, India – 500 091.
Uzma Taseen Research Scholar, Department of Pharmacology, Shadan College of Pharmacy, JNT Hyderabad University, Hyderabad, Telangana, India – 500 091.

DOI:

https://doi.org/10.52816/JDVAT.2022.2202

Keywords:

Rubia cordifolia, hyperlipidemia, antioxidant, toxicity, cholesterol.

Abstract

Hyperlipidemia, characterized by elevated cholesterol and triglyceride levels, poses a significant global health challenge with substantial implications for cardiovascular well-being. This study investigated the anti-hyperlipidemic potential of the methanolic root extract of Rubia cordifolia (MERC) using rat models induced with hyperlipidemia through a high-fat diet. Hyperlipidemia was induced by administering a highfat diet to rats for a duration of 4 weeks. MERC exhibited notable antioxidant activity in DPPH and reducing power assays. Treatment with MERC at doses of 200 and 400 mg/kg orally significantly mitigated hyperlipidemia, evidenced by reduced levels of serum Total Cholesterol (TC), Triglycerides (TG), LowDensity Lipoprotein Cholesterol (LDLC), and an increase in serum High-Density Lipoprotein Cholesterol (HDLC) compared to the vehicle control and the standard drug Atorvastatin. These findings underscore the substantial anti-hyperlipidemic activity of the methanolic root extract of Rubia cordifolia.