Formulation and In Vitro Evaluation of Tropisetron Loaded Microspheres

DOI: https://doi.org/10.52816/JDVAT.2021.1403

Abstract

Tropisetron is a 5-HT3 (5-hydroxytryptamine3) receptor antagonist used for the prevention of chemotherapy-induced nausea and vomiting. In the present study, ethyl-cellulose, sodium alginate and HPMC K15M loaded microspheres of tropisetron were successfully prepared by ionic gelation technique. All the formulations were evaluated for various parameters such as drug content, entrapment efficiency, in vitro dissolution study, release kinetic study and stability study. The in vitro dissolution studies showed that tropisetron microspheres formulation F10 have better sustained effect over a period of 12 hours which contains all three polymers having a perfect controlled release. The mechanism of release was determined by various kinetic equations such as zero-order, first-order, Higuchi, Hixon Crowell, Korsmeyer-Peppas and finding the R2 values of the release profile corresponding to each model. Thus, in the present study, in vitro drug release kinetic of the best formulation followed zero order release kinetic model and the drug release mechanism was anomalous diffusion. The results of the current study clearly indicate a promising potential delivery system of the tropisetron microsphere as an alternative to the conventional dosage form