Treatment of Oral Cancer by a Synthetic Analogue of Capsaicin & TRPV1 Antagonist: Capsazepine

Abstract

A synthesized homologue of the sensory neuron excitotoxin capsaicin is capsazepine. It was altered from capsaicin's chemical structure, which can act as a TRPV1 antagonist. It can interface with all of the monomer’s residues of the TRPV1 channel's transmembrane domain and connect to the channel's pores. By inhibiting the TRPV1 channel and reducing the flow of Ca2+, capsazepine can also have a number of other pharmacological properties. Capsazepine can have a variety of impacts on the survival and growth of cancer, including breast, ovarian, colon, oral, and osteosarcoma. It can also be used medically to treat other severe conditions such gastroenteritis, hepatitis, malaria, and seizures. According to reports, capsazepine shows pleiotropic anti-cancer activities against a variety of tumor cell lines.